Abstract
Background The cerebellum is classically considered mainly involved in motor processing, but recent studies have suggested several other functions, including pain processing. PET studies of acute migraine attacks have revealed activation of the cerebellum. In human pain imaging studies activation of the cerebellum is almost always observed, suggesting a role in nociception. Calcitonin gene-related peptide (CGRP) has been shown to be one of the most important neuropeptides involved in migraine pathology, where there is elevated release of CGRP during migraine attacks and CGRP receptor antagonists have antimigraine efficacy.
Highlights
The cerebellum is classically considered mainly involved in motor processing, but recent studies have suggested several other functions, including pain processing
Immunofluorescence was used to study the detailed distribution of Calcitonin gene-related peptide (CGRP) and its receptor components- calcitonin receptor-like receptor (CLR) and receptor activity modifying protein 1 (RAMP1)- in human and rhesus monkey cerebellum, using a set of newly characterized antibodies
[125I]CGRP binding was observed in the molecular layer of human cerebellum
Summary
The cerebellum is classically considered mainly involved in motor processing, but recent studies have suggested several other functions, including pain processing. PET studies of acute migraine attacks have revealed activation of the cerebellum. In human pain imaging studies activation of the cerebellum is almost always observed, suggesting a role in nociception. Calcitonin gene-related peptide (CGRP) has been shown to be one of the most important neuropeptides involved in migraine pathology, where there is elevated release of CGRP during migraine attacks and CGRP receptor antagonists have antimigraine efficacy
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