CGRP and Adrenomedullin as Pain-Related Peptides

Abstract

Calcitonin gene-related peptide (CGRP) and adrenomedullin (AM) belongs to the calcitonin gene-related peptide (CGRP) family, with a wide range of distribution and biological functions. CGRP is a well known pain transmitter and modulator highly expressed in primary sensory neurons. In this book chapter, we summarize current data on the role of CGRP in nociception and various types of pain conditions. We also discuss the effectiveness of peptide and non-peptide CGRP antagonists in treating these pathological pain states. Unlike CGRP, the role of AM in nociception and pathological pain conditions remains mostly unknown. However, recent anatomical and pharmacological findings suggest its role in nociception and some pain conditions. Future studies are proposed to uncover the mechanisms underlying the contribution of CGRP and AM in nociception and pathological pain conditions. Developing more selective small molecule antagonists of CGRP and AM receptors should thus be considered as promising therapeutic avenue to effectively treat various pain conditions.