Abstract
In vitro brainstem-spinal cord preparations isolated from neonatal (0–5 days old) rats were used to investigate the GABA B receptor-mediated modulation of the dorsal root evoked potentials in lumbar motoneurons recorded intracellularly. The GABA B receptor agonist, baclofen, at low concentrations (1–10 μM), caused a reduction of the amplitude of the monosynaptic excitatory postsynaptic potential (EPSP), in a concentration-dependent manner. The depression of EPSPs was likely exerted at a presynaptic level since it occurred without any significant change of the passive membrane properties of the motoneurons. The two GABA B receptor antagonists, CGP 35348 and CGP 55845A blocked the effects of baclofen. These two compounds may be useful tools to study the evolution of GABA B receptor-mediated presynaptic inhibition during ontogenesis.
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