Abstract
cGMP-dependent signaling pathways in spinal pain processing
Highlights
An exaggerated pain sensitivity is the dominant feature of inflammatory and neuropathic pain both in the clinical setting and in experimental animal models
To test the contribution of cGMP produced by NO-sensitive guanylyl cyclase (NO-GC) to pain sensitization, we investigated the localization of NO-GC in the spinal cord and in dorsal root ganglia, and we characterized the nociceptive behavior of mice deficient in NO-GC (GC-KO mice)
Our results provide evidence that NO-GC has a dominant role in the development of exaggerated pain sensitivity during inflammatory and neuropathic pain
Summary
Achim Schmidtko*1, Wei Gao, Peter König, Sandra Heine, Matthias Sausbier, Peter Ruth, Doris Koesling, Irmgard Tegeder, Andreas Friebe and Gerd Geisslinger. Address: 1Pharmazentrum Frankfurt/ZAFES, Institut für Klinische Pharmakologie, Goethe-Universität, Frankfurt am Main, Germany, 2Institut für Anatomie, Universität Lübeck, Germany, 3Pharmazeutisches Institut, Pharmakologie und Toxikologie, Universität Tübingen, Germany and 4Institut für Pharmakologie und Toxikologie, Ruhr-Universität, Bochum, Germany. Published: 11 August 2009 BMC Pharmacology 2009, 9(Suppl 1):S37 doi:10.1186/1471-2210-9-S1-S37. 4th International Conference of cGMP Generators, Effectors and Therapeutic Implications Meeting abstracts – A single PDF containing all abstracts in this Supplement is available here. http://www.biomedcentral.com/content/pdf/1471-2210-9-S1-info.pdf
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