Abstract
BackgroundConcentrated Growth Factors (CGF) is a concentration of second generation autologous growth factors compared to platelet rich plasma (PRP) and represents a multifactorial stimulation system that can be used for the management and treatment of chronic skin ulcers.AimThe aim of this work is to evaluate the additional benefits of the CGF compared to the standard of dressing and its effects on the dynamics of the healing process.MethodsAutologous CGFs were obtained from 100 patients with chronic mixed ulcers (venous ulcers in patients with II stage claudication) of the lower limbs in a multicentric controlled randomized study.ResultsThe results showed a significant advantage in the use of CGF in association with cleansing and selective compression in the healing time and stabilization of mixed ulcers of the lower extremities.ConclusionsThese results support the CGF’s clinical use for improving clinical outcomes in mixed ulcers of the legs.
Highlights
Concentrated Growth Factors (CGF) is a second-generation mixture of autologous growth factors compared to platelet rich plasma (PRP)
The results showed a significant advantage in the use of CGF in association with cleansing and selective compression in the healing time and stabilization of mixed ulcers of the lower extremities
Ulcers healing in group B occurred in the first phase of the study (12 week interval from first observation) only in 32 out of this 47 patients (68% of cases), with the following timing: in 2 patients (4.2%) in the first 5 weeks; in 1 patient (2.1%) in 6 weeks, in 3 patients (6.3%) in 8 weeks, in 5 patients (10.5%) in 9 weeks, in 7 patients (14.8%) in weeks, in 6 patients (13.9%) in weeks, in 8 patients (18.6%) in weeks, while in 15 patients (31.9%) wound healing was achieved over 12 weeks
Summary
Concentrated Growth Factors (CGF) is a second-generation mixture of autologous growth factors compared to platelet rich plasma (PRP). It represents a multifactorial stimulation system as it uses all phases of the blood. It is proposed for the ancillary treatment of chronic skin ulcers. Concentrated Growth Factors (CGF) is a concentration of second generation autologous growth factors compared to platelet rich plasma (PRP) and represents a multifactorial stimulation system that can be used for the management and treatment of chronic skin ulcers
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