Abstract
The cGAS-STING signaling pathway is an autoimmune inflammatory pathway that can trigger the expression of a series of inflammatory factors represented by type 1 interferon. Recent studies have found that the cGAS-STING signaling pathway played a significant role in liver physiology and was closely related to the progress of liver diseases. For example, activating the cGAS-STING signaling pathway could significantly inhibit hepatitis B virus (HBV) replication in vivo. Moreover, the cGAS-STING signaling pathway was also closely associated with tumor immunity in hepatocellular carcinoma (HCC). This review summarized the role of the cGAS-STING signaling pathway in several common liver diseases, especially the current application of the cGAS-STING signaling pathway in liver disease treatment, and prospected its future research, which provided a new idea for understanding and treating liver diseases.
Highlights
Liver disease is a major cause of illness and death, affecting many people worldwide
As an autoimmune inflammatory pathway, the cGAS-STING signaling pathway triggers an inflammatory storm associated with autophagy, immune escape, and mitosis
Accumulating evidence has implicated the important role of the cGASSTING signaling pathway in the pathogenesis of multiple liver diseases
Summary
Liver disease is a major cause of illness and death, affecting many people worldwide. When cGAS binds to dsDNA, the cGAS-STING signaling pathway is activated and induces the expression of type I IFNs and other inflammatory cytokines, triggering innate immune responses (Barber, 2015). As STING is widely expressed in various cell types and can regulate different pathways of programmed cell death, a deeper understanding of the cGAS–STING signaling pathway may bring a new dawn to treat infections, chronic inflammatory diseases, and even cancer. Researchers found that the cGAS–STING signaling pathway was closely related to the occurrence and development of multiple liver diseases. This review summarized the regulatory functions and mechanisms of the cGAS–STING signaling pathway in various liver diseases. The therapeutic value of this signaling pathway in liver diseases was discussed
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
