Abstract
cGAS and STING: At the intersection of DNA and RNA virus-sensing networks.
Highlights
It is clear that cyclic guanosine monophosphate (GMP)-adenosine monophosphate (AMP) synthase (cGAS) is essential in cytosolic recognition of DNA viruses, its role in restricting RNA virus infection is still inconclusive
It is apparent that stimulator of interferon genes (STING) is required for host responses against both DNA and RNA viruses
Studies of mechanisms employed by STING to restrict RNA virus infection have only just begun
Summary
Citation: Ni G, Ma Z, Damania B (2018) cGAS and STING: At the intersection of DNA and RNA virussensing networks. PLoS Pathog 14(8): e1007148. https://doi.org/10.1371/journal.ppat.1007148 Funding: This work was supported by National Institutes of Health grants DE028211, CA228172, CA096500, and CA019014 to BD. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Competing interests: The authors have declared that no competing interests exist.
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