Abstract
The adaptive immune system is increasingly appreciated for contributions to the exuberant and maladaptive immune response in Cystic Fibrosis (CF). We hypothesized that 1) CFTR-deficiency in mouse Th2 cells increases Th2 cytokine production, 2) CF mice have increased allergic inflammation when challenged with inhaled allergen, and 3) GATA-3 expression is increased in murine CFTR-deficient Th2 cells.
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