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Abstract
Intracerebroventricular (ICV) of the opioid like peptide, nociceptin/Orphanin (N/OFQ), produces marked effects on cardiovascular function and decreases in renal sympathetic nerve activity. The present study utilized changes in cFos immunocytochemistry expression to examine the hindbrain sites activated or inhibited, respectively, by ICV injection of N/OFQ in angiotensin II/high salt hypertensive rats (ANGII) as compared to ANGII rats injected with isotonic saline (control). The hindbrain was processed for cFos using a commercially available antibody (Oncogene AB‐5). ICV N/OFQ produced significant decreases in c‐Fos staining in the Area Postrema (C, 100.1 ± 26, ANGII; 69 ±21 P<.001) and anterior nucleus of the solitary tract (NTS) (C, 44 ± 14; ANGII 27 ± 10; P < .01). There were no statistical significant changes to the rostral ventrolateral medulla (RVLM), medium NTS, or locus coeruleus. Together, central ORL‐1 receptor activation in these forebrain regions may contribute directly to or indirectly participate in the neuropathways involved in the cardiovascular effects of N/OFQ
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