Abstract

Coating of particles is a widely used technique in order to obtain the desired surface modification of the final product, e.g., specific color or taste. Especially in the pharmaceutical industry, rotor granulators are used to produce round, coated pellets. In this work, the coating process in a rotor granulator is investigated numerically using computational fluid dynamics (CFD) coupled with the discrete element method (DEM). The droplets are generated as a second particulate phase in DEM. A liquid bridge model is implemented in the DEM model to take the capillary and viscous forces during the wet contact of the particles into account. A coating model is developed, where the drying of the liquid layer on the particles, as well as the particle growth, is considered. The simulation results of the dry process compared to the simulations with liquid injection show an important influence of the liquid on the particle dynamics. The formation of liquid bridges and the viscous forces in the liquid layer lead to an increase of the average particle velocity and contact time. Changing the injection rate of water has an influence on the contact duration but no significant effect on the particle dynamics. In contrast, the aqueous binder solution has an important influence on the particle movement.

Highlights

  • For various products in the pharmaceutical, chemical, and food industries, the coating of solid particles with different materials is an important processing step [1]

  • The particle dynamics in the fluidized bed can change during a coating process

  • A coating process in a rotor granulator was simulated with computational fluid dynamics (CFD)-discrete element method (DEM) considering capillary and

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Summary

Introduction

For various products in the pharmaceutical, chemical, and food industries, the coating of solid particles with different materials is an important processing step [1]. A wide range of equipment is available for coating, such as drum coaters, bubbling and spouting fluid beds, and fluidized bed rotor granulators In all these processes, it is crucial to consider the change of the particle dynamics due to an increasing amount of liquid in the apparatus. Neuwirth et al [3] investigated the particle dynamics in a fluidized bed rotor granulator under dry conditions experimentally and with CFD-DEM simulations. In our previous work [20], we simulated the two-phase spray nozzle with CFD-DEM to obtain the droplet distribution in the fluidized bed apparatus. A new coating model is implemented into the DEM code It describes the droplet deposition on the particles and the wall, as well as the drying of the liquid layer over time. The simulation results of the fluidization process without liquid injection are compared with two cases with different injection rates of water, as well as one case where an aqueous binder solution is sprayed in

CFD Modeling
DEM Modeling
Contact Force
Capillary Force
Viscous Force
Coating Model
Geometry of the Rotor Granulator
Simulation Parameters
Influence of Liquid Injection on Particle Dynamics
Particles colored bybyvelocity magnitude fordry thecase dryafter case
Influence of the Water Spray Rate and Coating Solution
Conclusions
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