Abstract
Abstract Cefixime is served as an important class of antibiotics for the treatment of infectious diseases in both human and animals. This is extensively used in the clinical practice and therapy to safeguard human health. The widespread use of cefixime and the need for pharmacological studies necessitates the development of fast, sensitive and accurate analytical technique/s to assay the presence of drug. In the present work, a novel and cost-effective electrochemical sensor has been developed for the electrochemical investigation of cefixime. The SEM, CV and EIS were used for electrodes characterization. At CTAB/AuNPs/PGE the oxidation of cefixime was found to be irreversible and diffusion-controlled. The linearity was established in the range of 10 × 10−9 to 30 × 10−8 M with detection limit of 1.21 × 10−10 M. The applicability of the proposed electrochemical sensor has been successfully illustrated by the estimation of cefixime present in pharmaceutical formulations and biological fluids.
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