CETP genotype and concentrations of HDL and lipoprotein subclasses in African-American men.

Abstract

Aim: To assess the association between theCETP Taq1B and I405V polymorphisms with levels of lipoprotein subclasses in African-American (AA) men with and without Type 2diabetes (T2DM). Patients & methods: AA men, over 30 years of age, with (n=54) or without T2DM (n=50), and not receiving lipid-lowering agents, underwent advanced lipid analysis and genotyping. Results & conclusion: In the total patient population Taq1B B2-allele carriers had significantly higher levels of large HDL subclasses (HDL-2b [p=0.017] and HDL-L [p=0.019]), lower levels of small-HDL subclasses (HDL-3a [p =0.004] and HDL-3b [p=0.031]), and lower levels of LDL subclasses (LDL-IVa [p=0.012] and LDL-IIIb [p=0.009]). The only significant genotype-diabetes interaction occurred with the HDL-2a subclass (p=0.015). No statistically significant associations were seen with I405V genotype. Our observations of lower levels of small-HDL and higher levels of large-HDL suggest that a potentially important HDL subclass-CETP relationship exists.