Abstract
(1) Background: The microbiome consists of microorganisms from various kingdoms with numerous physical and chemical properties Lactobacillus species constitute the highest percentage of healthy cervical and vaginal microbiota. Dysbiosis may cause adverse outcomes, e.g., bacterial vaginosis, pelvic inflammatory disease and pregnancy complications. The cervicovaginal microbiome might contribute to the development of a persistent HPV infection—the main risk factor of cervical cancer—and influence progression to malignancy The aim is to perform a systematic review of current literature and a meta-analysis regarding microbiome changes after cervical intraepithelial neoplasia treatment. (2) Methods: We will search PubMed, Scopus, Google Scholar and Embase Database and trace citations in the reference sections. Randomized and non-randomized controlled studies, case–control and cohort studies published between January 2000 and May 2021 will be included in the study protocol. The following keywords will be used: ‘microbiome’, ‘vaginal microbiome’, ‘cervical microbiome’, ‘cervical neoplasia treatment’, ’conization’, ‘electroconization’, and ‘electrosurgical treatment’. Statistical analyses will be performed using RevMan 5.4. (3) Results: The results will be published as a peer-reviewed article. (4) Conclusions: The study will show which forms of intraepithelial neoplasia treatment change the cervicovaginal microbiome. Finding the best form of treatment by studying the cervicovaginal microbiome after various forms of treatment is essential. Patients would benefit not only from the treatment of the initial disease but also the management of dysbiosis, which might underlie other pathologies.
Highlights
Introduction published maps and institutional affilThe precise definition of the human microbiome was presented by Berg et al in 2020
Dysbiosis, which is an imbalance between the species of microorganisms, may contribute to the development of numerous adverse outcomes
A lot of evidence is available to support the fact that the microbiome may lead to the persistence of an Human papilloma virus (HPV) infection and result in cervical neoplasia [4]
Summary
The precise definition of the human microbiome was presented by Berg et al in 2020. It was described as a group of microorganisms originating from various kingdoms, occurring in specific areas, with an array of physical and chemical properties [1]. The female lower reproductive tract is an area where microorganisms are present at high concentrations, with. Dysbiosis, which is an imbalance between the species of microorganisms, may contribute to the development of numerous adverse outcomes. The most common ones associated with the genitourinary tract are bacterial vaginosis and pelvic inflammatory disease, and negative pregnancy outcomes such as miscarriage and preterm birth [3]. The risk factors contributing to dysbiosis, such as nicotine use, contraceptive use and parity, were correlated with malignancy in iations
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