Cervicovaginal interleukin-6 as a predictor of preterm birth in African American women

Abstract

BackgroundIdentification of women who will deliver preterm may reduce infant morbidity and mortality. In heterogeneous populations, fetal fibronectin (fFN) and interleukin-6 are excellent predictors of women who will not deliver within two weeks. African-Americans are at higher risk for preterm birth than Caucasians. This study compares the diagnostic utility of fFN and interleukin-6 in cervicovaginal fluid (CVF) to predict preterm birth within 14days of sampling in African-American and Caucasian women. MethodsInterleukin-6 was measured in 667 CVF samples from 580 women with and without symptoms of labor. The utility of CVF interleukin-6 and fFN to predict delivery was determined in the total population and in African-Americans and Caucasians separately. ResultsfFN positive (≥50μg/l) results were associated with delivery in ≤14days in African-Americans (Odds Ratios (OR) 8.7; Likelihood Ratio (LR) 3.7) (p<0.0001) and Caucasians (OR 11.9; LR 5.7) (p<0.01). A positive interleukin-6 (≥250ng/l) was associated with delivery in ≤14days in African-Americans (OR 12.7; LR 5.25) (p<0.0001), but not in Caucasians (OR 4.1; LR 3.2) (p=0.13). ConclusionsCVF interleukin-6 and fFN have similar diagnostic utilities in a diverse population. Interleukin-6 more accurately predicts delivery within 14days in African-Americans, while fFN is more accurate in Caucasians.