Abstract
Genital warts are due to an increasingly prevalent venereally spread virus infection. Typical condylomas affect vulval, vaginal and both original and metaplastic cervical squamous epithelia. The cervix is involved more commonly than formerly realized. A significant number of cervical lesions are not typical condylomas, but have a rather flat contour and such cases have been under-diagnosed in the past. Cellular atypia is common, confusion with dysplasia has occurred and wart virus infection is thought to be the basis of many reported so-called mild dysplasias which regressed spontaneously. There has been speculation about the possible premalignant significance of cervical warts. This suggestion is supported to some extent by the known but rare occurrence of malignant change in condylomas, and by the fact that flat cervical warty lesions resemble histologically epidermodysplasia verruciformis, a non-genital wart virus infection which is frequently followed by squamous carcinoma. The cytological, histological and ultrastructural features of two illustrative non-condylomatous cervical wart virus lesions will be shown.
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