Abstract
The effect on cervical mucus penetration by treatment of spermatozoa in normal ejaculates from 1 donor with different volumes of rabbit antiserum against seminal plasma seminal spermatozoa spermatocele spermatozoa and with serum from men with different levels of sperm antibodies was studied. Samples from 6 other men were also treated with antiseminal plasma serum and with serum containing sperm antibodies. The untreated spermatozoa and that treated with control sera showed normal penetration and unimpaired motility. Antisera against seminal plasma seminal spermatozoa and spermatocele spermatozoa had immobilizing and agglutinating activity and caused a reduction of penetration. Samples from the 6 different donors treated with rabbit antiserum or patient serum were affected but the penetration of those with high percentages of motile spermatozoa and rapid sperm motility was less reduced. It is concluded that antibodies against human spermatozoa and seminal fluid cause reduction of the cervical mucus-penetrating ability of spermatozoa with the degree dependent on antibody concentration and intrinsic properties of the spermatozoa.
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