Abstract
Persistent inflammatory smear is a benign finding on pap test but is associated with premalignant lesion of the cervix. Further evaluation is therefore necessary. This study was done to determine the prevalence of cervical intraepithelial lesions in women with persistent inflammatory smear. This is descriptive observational study conducted in Department of Obstetrics and Gynaecology of tertiary care centre of Nepal from 15th May 2020 to 14th May 2021 after obtaining ethical clearance from Institutional Review Board (Reference no MEMG/IRC/338/GA). Women with two consecutive pap smear reports showing inflammatory findings were enrolled. Colposcopy was performed and Modified Reid's colposcopic index was used to grade the lesions. Colposcopic guided biopsy was taken and tissue sent for histopathology for abnormal colposcopic lesions. Data analysis was done using Statistical Package for Social Sciences version 21 and frequency and percentages were used to present data. Point estimate at 95% Confidence Interval was calculated along with frequency and proportion for binary data. Among 115 women, 57 (49.5%) at 95% Confidence Interval (40.37-58.63) had Cervical Intraepithelial lesions. Among them 48 (41.7%) had low grade intraepithelial lesions and 9 (7.8%) had high grade lesions on colposcopy. The prevalence of cervical intraepithelial lesions in women with persistent inflammatory smear on pap was higher in our study compared to other studies.
Highlights
Persistent inflammatory smear is a benign finding on pap test but is associated with premalignant lesion of the cervix
Though a benign finding in pap smear, persistent inflammatory smears have been found to be associated with preneoplastic changes.[6,7,8,9]
Inflammatory smear as a finding in pap smear is quite common but there is no consensus to the further treatment
Summary
Persistent inflammatory smear is a benign finding on pap test but is associated with premalignant lesion of the cervix. This study was done to determine the prevalence of cervical intraepithelial lesions in women with persistent inflammatory smear. Inflammatory smear is one of the common findings noted in pap smear.[1,2,3] Cervical inflammation is mostly due to infections.[3,4] it may occur following chronic irritation from foreign body, trauma and chemical irritants.[5] Persistent inflammatory smear is when two consecutive smears reports show inflammatory changes without atypia. Though a benign finding in pap smear, persistent inflammatory smears have been found to be associated with preneoplastic changes.[6,7,8,9] Deferring further evaluation with colposcopy and guided biopsy whenever necessary may delay timely diagnosis of precancerous lesions in many
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