Abstract
ObjectiveTo evaluate the association between cervical human papillomavirus (HPV) infection at the time of admission and the presence of microbial invasion of the amniotic cavity (MIAC) and intra-amniotic inflammation (IAI) in women with preterm prelabor rupture of membranes (PPROM) and to determine the association between cervical HPV infection and short-term neonatal morbidity.MethodsOne hundred women with singleton pregnancies complicated by PPROM between the gestational ages of 24+0 and 36+6 weeks were included in the study. The presence of HPV DNA was evaluated in scraped cervical cells using polymerase chain reaction (PCR). Amniotic fluid samples were obtained by transabdominal amniocentesis.ResultsThe rate of cervical HPV infection in women with PPROM was 24%. The rates of MIAC and IAI were not different between women with cervical HPV infection and those without cervical HPV infection [MIAC: with HPV: 21% (5/24) vs. without HPV: 22% (17/76), p = 1.00; IAI: with HPV: 21% (5/24) vs. without HPV: 18% (14/76), p = 0.77]. There were no differences in the selected aspects of short-term neonatal morbidity between women with and without cervical HPV infection.ConclusionsIn women with PPROM, the presence of cervical HPV infection at the time of admission is not related to a higher risk of intra-amniotic infection-related and inflammatory complications or worse short-term neonatal outcomes.
Highlights
Preterm prelabor rupture of membranes (PPROM), defined as the rupture of fetal membranes and leakage of amniotic fluid before the onset of regular uterine activity prior to a gestational age of 37 weeks, is responsible for about one-third of preterm deliveries and complicates approximately 2–8% of all pregnancies [1,2,3]. PPROM has been considered a non-infectious disease, many PPROM pregnancies are still complicated by infection-related and inflammatory conditions such as microbial invasion of the amniotic cavity (MIAC) and/or intra-amniotic inflammation (IAI) [4,5,6,7]
There were no differences in the selected aspects of short-term neonatal morbidity between women with and without cervical human papillomavirus (HPV) infection
In women with PPROM, the presence of cervical HPV infection at the time of admission is not related to a higher risk of intra-amniotic infection-related and inflammatory complications or worse short-term neonatal outcomes
Summary
PPROM has been considered a non-infectious disease, many PPROM pregnancies are still complicated by infection-related and inflammatory conditions such as microbial invasion of the amniotic cavity (MIAC) and/or intra-amniotic inflammation (IAI) [4,5,6,7]. These complications can be considered as gestational age-dependent, since their presence decreases with advancing gestational age of development of PPROM [6, 7]. The presence of Lactobacillus crispatus as a dominant bacterium in the cervical compartment has a protective effect against the development of intra-amniotic complications [9]
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