Abstract
Cervical Esophageal Cancer: A Comparison of Outcomes by Treatment Paradigm, Tumor Location, and Histology Using the National Cancer Database
Highlights
Purpose/Objective(s): The most appropriate treatment for cervical esophageal cancer (CEC) remains controversial, with some favoring a head & neck (H&N) paradigm (>60 Gray [Gy] and single-agent chemotherapy) and others favoring an Esophageal paradigm (60 Gy or less and multiagent chemotherapy)
Purpose/Objective(s): In head and neck cancer (HNC), the high-risk category is defined by histopathology showing nodal metastasis with extracapsular spread (ECS) and/or tumor-positive surgical margins
The intermediate-risk (IR) designation is characterized by pathology other than those mentioned in the preceding risk groups. The goals of this retrospective study were to determine the long-term results of postoperative radiation therapy (PORT) administered to individuals with IR-HNC and to compare the outcomes in two histopathologic subgroups of IR-HNC to assist in defining which patients are more appropriate candidates for PORT
Summary
Purpose/Objective(s): The most appropriate treatment for cervical esophageal cancer (CEC) remains controversial, with some favoring a head & neck (H&N) paradigm (>60 Gray [Gy] and single-agent chemotherapy) and others favoring an Esophageal paradigm (60 Gy or less and multiagent chemotherapy). Purpose/Objective(s): In head and neck cancer (HNC), the high-risk (for recurrence) category is defined by histopathology showing nodal metastasis with extracapsular spread (ECS) and/or tumor-positive surgical margins. The goals of this retrospective study were to determine the long-term results of postoperative radiation therapy (PORT) administered to individuals with IR-HNC and to compare the outcomes in two histopathologic subgroups of IR-HNC to assist in defining which patients are more appropriate candidates for PORT. Locoregional relapse occurred less often in the advanced tumor patient subgroup than in the nodal metastases cohort (16% vs 24%, respectively; P Z .29); the corresponding proportions of distant metastases relapses were 21% and 15%, respectively (P Z .66).
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