Abstract
Human papillomavirus (HPV) infection is highly prevalent in sexually active adolescent and young adult women. Although infection frequently is asymptomatic, it may be associated with the development of condylomata and cervical carcinoma. Recent information about the natural history of HPV infection and abnormal cytology in adolescent and young adult women, as well as the availability of HPV DNA testing and new techniques for cytologic screening, have led to a comprehensive reassessment of current screening and management strategies in young women. In this review we will summarize new data on the natural history of HPV infection and cytology in young women, review the limitations of cervical cytology and resulting new technologies for cytologic screening and HPV DNA testing, and present strategies for cytologic screening and management of abnormal cytology in adolescent and young adult women.
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