Abstract
The term CUP syndrome (cancer of unknown primary) refers to amultifaceted clinical picture in which the affected patients have lymph node and/or distant metastases without the location of the primary tumor being known. The criteria of CUP syndrome are fulfilled if ahistologically or cytologically confirmed malignancy is present without adetectable primary tumor after completion of the primary diagnosis. Due to the usually poor prognosis and the manifold appearance, which often does not allow astandardized therapy, cervical CUP syndrome makes specific demands on clinical and imaging diagnostics. Using modern techniques such as positron emission tomography-computed tomography (PET-CT), imaging plays akey role in the detection of apossible occult primary tumor as well as in staging and prognosis assessment.
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