Abstract
ObjectiveThis study examined whether there is a positive correlation existed between cervical and oral High Risk-Human Papilloma Viruses (HR-HPV) types 16, 18 infections in patients with clinically confirmed cervical lesions.MethodsIn this study 50 participants were included (40 were cases and 10 were controls). One hundred DNA materials (50 were cervical and 50 were oral epithelial tissues) were analyzed using HR-HPV subtypes 16 and 18 specific PCR probes.ResultsOf the 40 cases, HR-HPV 16, 18 were identified in 16/40 (40%), of the cervical tissues of whom 8/16 (50%) were positive for HPV 16; 6/16 (37.5%) were identified with HR-HPV 18, and 2/16 (12.5%) were detected with both HR-HPV subtypes. All of the clinically healthy cases were found negative. Only one oral tissue sample (case) was 1/40 (2.5%) was found positive for HPV subtype16.ConclusionThe frequency of infection with HR-HPV subtypes 16 and 18 is high among Sudanese women with cervical lesions and suggests a role of HR-HPV in the development of cervical cancer in Sudan. No correlation between cervical and oral HPV infection was noted. Further study with screening of large number of patients with cervical cancer is recommended for further clarification of these findings.
Highlights
Cervical cancer is the second most common cancer found in women with approximately 530,000 new cases each year resulting in an estimated 275,000 deaths, worldwide
The researchers have proposed that Human Papilloma Viruses (HPV) testing of self-collected Pap specimens
HPV-18 is thought to account for approximately 50% of all adenocarcinomas [19]
Summary
Cervical cancer is the second most common cancer found in women with approximately 530,000 new cases each year resulting in an estimated 275,000 deaths, worldwide. Cervical cancer incidences have declined, mostly due to cervical cytology screening campaigns, which requires significant medical resources and laboratory infrastructure. Cervical cancer is on the rise in the developing world, with one-seventh of the world’s cervical cancer cases in China, where no nationwide screening program for the disease currently exists [1]. In Sudan, cervical cancer is the second most common cancer type among women [2] and there are 923 new cases representing 4.5/100,000 [3]. The low-risk types (HPV 6, 11, 40, 42, 43, 44, 54, 61, 70, 72, 81, and CP6108) can cause mild cervical dysplasia but are rarely associated with severe cervical dysplasia or cervical carcinoma [8,9]
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