Abstract
Cervical adenoid basal carcinoma (ABC) rarely can harbor associated malignancies like adenoid cystic carcinoma or squamous cell carcinoma (SCC), which express markedly different prognosis from a pure ABC, making an appropriate biopsy essential to provide a clear diagnosis and therapeutic plan. We report a 64-year-old asymptomatic lady with an abnormal cervical cytology, who underwent a conization to reveal an ABC with overlying microinvasive SCC. Doubtful resection margins led us to perform radical hysterectomy with lymph node dissection. Subsequent pathological examination showed a true invasive SCC co-existing with ABC, with invasion of the parametrium. Unlike the indolent course of many pure ABC patients, the prognosis of 11 previously reported co-existing invasive SCC with ABC patients appears to depend on the SCC component. Our case reiterates the importance of adequate biopsy with careful interpretation to cover the possibility of a co-existent malignancy. Besides, it presents an argument in favor of radical surgery for the primary treatment of suspicious associated malignancy, and supports adjuvant treatment according to the unfavorable extent of the co-existent invasive carcinoma.
Highlights
Adenoid basal carcinoma (ABC) is a rare cervical malignancy accounting for less than 1% of all cervical cancers [1]
We report an uncommon association of an invasive squamous cell carcinoma (SCC) with an ABC
Among different malignancies in the classification of basaloid lesions of the uterine cervix proposed by Grayson and Cooper [14], there was a spectrum of basaloid carcinomas which were stated of histopathologic similarities
Summary
Adenoid basal carcinoma (ABC) is a rare cervical malignancy accounting for less than 1% of all cervical cancers [1]. ACC and basaloid squamous cell carcinoma (BSCC), which morphologically closely resemble ABC, have an aggressive clinical course often associated with recurrence and metastasis [4,5,6]. We report an uncommon association of an invasive squamous cell carcinoma (SCC) with an ABC.
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