Ceruloplasmin: A Surrogate Marker of Osteoporosis

Abstract

Abstract Introduction/Objective Osteoporosis is a bone disorder and is currently a major global health issue. Ceruloplasmin (CP) is an acute phase reactant and antioxidant, characterized by ferroxidase activity and increases in inflammation. C-reactive protein (CRP), an acute phase protein belonging to pentraxin family of proteins. This study was designed to investigate the role of acute phase reactants Ceruloplasmin and CRP in the screening of osteoporosis. The objective of this paper is to evaluate the role of serum Ceruloplasmin and C-reactive protein as biomarkers of osteoporosis. Methods/Case Report This study was conducted in the Bone Clinic and the biochemistry department of a tertiary care hospital. One hundred and twenty participants were included in the study belonging to the age group of 50 to 80 years. Participants in the group were divided into two groups, group I: comprising of patients with osteoporosis, and group II: consisting of patients without osteoporosis (n=56) (control group) (n=64). Patients were classified into two groups on the basis of Bone Mineral Density measurements using dual-energy. X-ray absorptiometry scanning. CRP and serum CP levels were analyzed in blood samples by immunoturbidimetry. Results (if a Case Study enter NA) Serum ceruloplasmin levels were significantly higher in Osteoporosis patients as compared to the control group. A significant positive correlation (r= 0.92, p<0.05 ) was observed between higher serum levels of CP and higher levels of CRP in the Osteoporosis patients. There was a significant difference in the CP levels of the osteoporosis group (68.4± 7.2 mg/dl ) and the control group (37.3 ± 4.9 mg/dl) (p<0.05). CRP levels also differed significantly among the osteoporosis patients (2.23± 0.68 mg/dl) and the control participants (1.07± 0.42 mg/dl) (p<0.05). Conclusion Our study demonstrates that the measurement of serum ceruloplasmin levels has the potential as a surrogate marker for patients with osteoporosis