Abstract
Manifold uses of heteroatom directed ortho-metalation which is responsible for its wide application in aromatic and heteroaromatic chemistry include regiocontrolled introduction of substitutents in aromatic or heteroaromatic ring and manipulation of introduced functionalities leading to chain extension and ring annulation. Metalated compounds also undergo a variety of anionic rearrangements providing synthetic strategies to target molecules. In this article work carried out in the authors’ laboratory on the application of this methodology in the field of sulfur heterocycles is reviewed.
Highlights
IntroductionThe intellectually stimulating chemistry involved in the synthesis, reactivity and rearrangement of heterocyclic compounds apart from their numerous uses is responsible for the unabated interest of organic chemists in heterocyclic chemistry
Manifold uses of heteroatom directed ortho-metalation which is responsible for its wide application in aromatic and heteroaromatic chemistry include regiocontrolled introduction of substitutents in aromatic or heteroaromatic ring and manipulation of introduced functionalities leading to chain extension and ring annulation
Our interest over the past two decades was principally focused on many facades of sulfur heterocycles, a large part of which concerned application of heteroatom directed ortho metalation.[1]
Summary
The intellectually stimulating chemistry involved in the synthesis, reactivity and rearrangement of heterocyclic compounds apart from their numerous uses is responsible for the unabated interest of organic chemists in heterocyclic chemistry. Our interest over the past two decades was principally focused on many facades of sulfur heterocycles, a large part of which concerned application of heteroatom directed ortho metalation.[1]
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