Cerium-based Dual-Modality Imaging Contrast Agent for Efficient Retention in Tumor Acidic Microenvironment

Abstract

Design and fabrication of highly effective, targeted, intelligent and multifunctional innovative theranostic agents with innovative alternative materials become pressing concerns. Nanoparticles are suitable for the incorporation of multifunction by modulating such a specific structure in a nanoscale and have been developed as multifunctional intelligent contrast agent theranostic nanoplatform on account of being performed multifunctional integration easily, for instance, controlled release function, targeting function, multi-stimuli sensitive function, biocompatibility, bio-degradation and other functions for promoting performance, effectiveness and efficiency. In this work, the CdTe@SiO 2 @CeO 2 core-shell nanoparticles were synthesized and assessed as a pH responsive dual-modality imaging contrast agent. The CdTe@SiO 2 core was participated as fluorescent label and the CeO 2 shell was partaken as CT tag. As a latent auxiliary scheme, this study explored the dual-modality combination between fluorescence imaging and CT imaging to localize tumor on the xenograft tumor models. All assessments acknowledged that this CdTe@SiO 2 @CeO 2 core-shell nanoparticle was an effective dual-modality contrast medium for tumor mapping on murine tumor models. The development of nanoparticulate contrast agents for multimodality diagnostic imaging and therapy has been intensively pursued in recent years. In this work, a pH responsive fluorescent-CT dual-modality imaging contrast agent was synthesized and assessed on murine tumor models. It's an effective fluorescent-CT dual-modality contrast medium for tumor mapping on murine tumor models, and a great potentiality would be demonstrated in surgical guidance in future clinic application.