Abstract
Cerenkov luminescence imaging (CLI) is a cost-effective molecular imaging tool for biomedical applications of radiotracers. The introduction of Cerenkov luminescence tomography (CLT) relative to planar CLI can be compared to the development of X-ray CT based on radiography. With CLT, quantitative and localized analysis of a radiopharmaceutical distribution becomes feasible. In this contribution, a feasibility study of in vivo radiopharmaceutical imaging in heterogeneous medium is presented. Coupled with a multimodal in vivo imaging system, this CLT reconstruction method allows precise anatomical registration of the positron probe in heterogeneous tissues and facilitates the more widespread application of radiotracers. Source distribution inside the small animal is obtained from CLT reconstruction. The experimental results demonstrated that CLT can be employed as an available in vivo tomographic imaging of charged particle emitters in a heterogeneous medium.
Highlights
Optical molecular imaging is a typical multidisciplinary method promoted by biological, physical and chemical sciences [1]
Coupled with the information on the anatomy of the small animal, the reconstructed distance error was reduced. These encouraging results proved that optical property heterogeneity can help Cerenkov luminescence tomography (CLT) reconstruction
Source depth and flux density distribution in the mouse were calculated by the rule of CLT reconstruction
Summary
Optical molecular imaging is a typical multidisciplinary method promoted by biological, physical and chemical sciences [1]. Cerenkov luminescence is emitted from Cerenkov radiation [5] during the initial decay process of medical isotopes These Cerenkov photons are detected with a low-noise charge-coupled device (CCD) and converted into optical images, which is Cerenkov luminescence imaging (CLI). As an optical molecular imaging method, CLI can quantitatively map [7] the distribution of radionuclides, such as 18F, 131I, and 225Ac. In order to obtain spatial and/or temporal localization information of the radioactive source inside the medium, Li et al [8] proposed the corresponding Cerenkov luminescence tomography (CLT), assuming that the scattering and absorption properties of tissues were homogeneous. The model-based iterative reconstruction is applied to in vivo radioactive optical imaging in the paper. The results of the physical experiments on nude mice demonstrated that the proposed technique with a priori structural information incorporated in the CLT inverse problem can improve the quality of source reconstruction
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