Abstract
A gas-liquid Chromatographie method was used to study polyols in the cerebrospinal fluid of 29 diabetic patients and 12 non-diabetic subjects. The presence of several polyols was verified. The level of sorbitol was higher in diabetic patients than in the non-diabetic subjects. The degree of correlation between the level of sorbitol in cerebrospinal fluid and blood glucose was highly significant. On the other hand, the level of sorbitol was not elevated in the urine of the diabetic patients. The data suggest that the level of sorbitol in cerebrospinal fluid reflects a metabolic derangement of the nervous tissue that occurs in patients with diabetes mellitus.
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