Abstract
Magnesium (Mg) is an essential cofactor for many enzymatic reactions, especially those involved in energy metabolism. The aim of the present study was to determine the CSF concentration of Mg in various neurological disorders (n = 72) and in healthy subjects (n = 75). The control group included 35 males and 40 females, aged 16-89 years (mean age 53 years) who were subjected to a lumbar puncture for diagnostic reasons. The CSF examination was normal mainly as concerns the macroscopically examination, the leukocyte count and the protein level. The determination of Mg was performed with xylidyl-blue photometry. Our normal CSF Mg mean value was 0.97 ± 0.08 mmol/l (range 0.6-1.4 mmol/l). In the group of patients (n = 11) with convulsive seizures a slightly but significantly lower Mg were revealed (0.92 ± 0.03 mmol/l; p = 0.001; paired two-tailed Student’s t-tests). No statistically significant change of CSF Mg levels was noted in patients suffering from alcohol withdrawal syndrome, multiple sclerosis or Bell’s palsy. Our results indi-cate that magnesium deficiency may play a role for seizure manifestation even in patients with a moderate low Mg without neurological signs. Low CSF magnesium is associated with epilepsy, further studies may determine the influ-ence of anti-epileptic drug therapy on CSF magnesium levels.
Highlights
The significance of trace elements concentration in the serum and various body fluids has been demonstrated in a number of publications
No statistically significant change of cerebrospinal fluid (CSF) Mg levels was noted in patients suffering from alcohol withdrawal syndrome, multiple sclerosis or Bell’s palsy
Our results indicate that magnesium deficiency may play a role for seizure manifestation even in patients with a moderate low Mg without neurological signs
Summary
The significance of trace elements concentration in the serum and various body fluids has been demonstrated in a number of publications. Magnesium determinations in the cerebrospinal fluid (CSF) in neurological diseases has been reported only in a small number of communications [1,2,3]. It has been suggested that low serum Mg has occasionally been associated with significant effects on the central nervous system especially in epilepsy and alcoholism. Further studies in the future may determine the influence of anti-epileptic drug therapy on CSF magnesium levels. The existing knowledge about the impact of magnesium on epilepsy and other neurological diseases is poor and controversial. In this study, we purposed evaluation of the level of CSF concentration of Mg in a total of seventy-two neurological patients and seventy-five healthy controls
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