Abstract
Encephalitis is an inflammatory disease of the central nervous system most usually caused by a viral infection. Autoimmune encephalitis is also common. The mechanism of action of various vaccines aim to elicit immune response. Major neurological complications indicative of vaccination-related autoimmune encephalitis and acute encephalitis after the first dose of mRNA COVID-19 vaccines have been reported. We present a 59-year-old female patient with subtle initiation of cognitive and behavioral deterioration two months after the second dose of SARSCoV-2 vaccine. Diagnostic work-up was suggestive of encephalitis. The findings fulfilled the criteria for possible autoimmune encephalitis related to prior vaccination with detected cytokine elevation.
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