Abstract
The CSF withdrawn from spontaneous morphine abstinent rat and administered into the lateral ventricle of morphine dependent rat, precipitates a behavioural withdrawal syndrome. This effect is absent in naive recipients. Similarly, the CSF from naive donors or CSF made artificially did not affect a behaviour of naive or morphine dependent recipients. The CSF-induced withdrawal is characterized by decrease of visual evoked potential peak latency (N3) and amplitude values (N2-P3 and P3-N3). These effects were qualitatively identical, but less prominent than corresponding symptoms observed during to naloxone-precipitated withdrawal. However, in contrast to naloxone, the CSF from spontaneous morphine abstinent rat does not exert a contraction of isolated morphine dependent ileum
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