Abstract
An isolated clinical observation led to the study, in the experimental laboratory, of some of the effects produced in the cerebrospinal fluid by continuous subarachnoid drainage. The case in question was one of meningeal infection; treatment consisted in creating a lumbar subarachnoid fistula. The intake of fluid was kept constantly between 4000 and 5000 cc. per twenty-four hours. The drainage of spinal fluid was estimated as 800 or 1000 cc. per day; this figure was obtained by weighing the dressings before and after saturation. The urinary output during the time that the spinal fluid escaped was from 1600 to 2000 cc. every twenty-four hours. After the spinal fistula healed, it was found that the urinary output increased approximately 1 liter, when the total intake of fluid and the other conditions remained essentially the same. These observations led to the belief that large quantities of water and perhaps of other inorganic
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