Abstract
Obstruction to cerebrospinal fluid (CSF) flow in idiopathic normal pressure hydrocephalus (iNPH) results in reduced CSF total tau (t-tau) and amyloid-β 42 (Aβ42) protein concentrations [1]. Restoration of normal CSF flow dynamics with ventriculoperitoneal (VP) shunt allows these biomarkers to clear from extracellular fluid into the CSF(1). CSF biomarkers in iNPH have been an interesting subject with initials results suggestive of reduced t-tau and amyloid-β. A subgroup of probable iNPH patients responds favorably to VP shunt insertion but for a brief period (temporary responders). In our unit, these patients are further investigated with assessment of the effect of shunt tapping on walking speed. A large proportion underwent shunt revision. In this population, CSF biomarkers were studied over a prolonged period of time.
Highlights
Obstruction to cerebrospinal fluid (CSF) flow in idiopathic normal pressure hydrocephalus results in reduced CSF total tau (t-tau) and amyloid-b 42 (Ab42) protein concentrations [1]
CSF biomarkers in idiopathic normal pressure hydrocephalus (iNPH) have been an interesting subject with initials results suggestive of reduced t-tau and amyloid-b
A subgroup of probable iNPH patients responds favorably to VP shunt insertion but for a brief period. These patients are further investigated with assessment of the effect of shunt tapping on walking speed
Summary
Obstruction to cerebrospinal fluid (CSF) flow in idiopathic normal pressure hydrocephalus (iNPH) results in reduced CSF total tau (t-tau) and amyloid-b 42 (Ab42) protein concentrations [1]. Cerebrospinal fluid biomarkers in patients with idiopathic normal pressure hydrocephalus with temporary response to shunt insertion Huan Wee Chan*, Patricia Anne Haylock-Vize, Edward William Dyson, Aswin Chari, Claudia Craven, Samir A Matloob, Neekhil A Patel, Simon D Thompson, Syed N Shah, Andrew R Stevens, Jinendra Ekanayake, Ahmed K Toma, Laurence Dale Watkins Introduction Obstruction to cerebrospinal fluid (CSF) flow in idiopathic normal pressure hydrocephalus (iNPH) results in reduced CSF total tau (t-tau) and amyloid-b 42 (Ab42) protein concentrations [1].
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