Cerebrospinal fluid anti-Epstein-Barr virus specific oligoclonal IgM and IgG bands in patients with clinically isolated and Guillain-Barré syndrome.

Diana Ferraro,Francesca Vitetta,Veronica Galli,Elisa Merelli,Anna Maria Simone,Roberta Bedin,Patrizia Sola,Paolo Frigio Nichelli

doi:10.1007/s13365-016-0493-9

Abstract

Epstein-Barr virus (EBV) has been implicated in multiple sclerosis (MS) pathogenesis. We aimed to assess the frequency of EBV-specific IgG and IgM oligoclonal bands (OCB) in cerebrospinal fluid (CSF) of 50 patients with clinically isolated syndrome (CIS) and in 27 controls with Guillain-Barré syndrome (GBS). Furthermore, we assessed correlations between the presence of OCB and CIS patients' CSF, MRI, and clinical variables. There was no difference in the proportion of CIS and GB patients with positivity for anti-EBV-specific IgG/IgM OCB. There were no correlations between OCB and analyzed variables, nor were they predictive of a higher disability at 3years.

Highlights

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We obtained the approval In clinically isolated syndrome (CIS), cerebrospinal fluid (CSF)-restricted Epstein-Barr virus (EBV)-specific IgG oligoclonal bands (OCB) 142
168 In the present study, we found no differences in the proportion CSF of CIS patients does not differ from that of control sub- 190

Summary

Introduction

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