Abstract
目的 探讨脑脊液和血清S-100B蛋白含量变化对病毒性脑炎患儿脑损伤的评估价值.方法 将56例病毒性脑膜炎患儿分为无昏迷组(40例)与昏迷组(16例).采用酶联免疫吸附试验双抗体夹心法检测56例病毒性脑炎患儿和16例非神经系统疾病患儿脑脊液和血清中的S-100B蛋白含量,并进行动态观察.结果 (1)昏迷组的脑脊液和血清S-100B蛋白含量显著高于无昏迷组,无昏迷组S-100B蛋白含量与对照组有差异.(2)脑脊液和血清中S-100B蛋白的变化随着病毒性脑炎患儿的病情变化而发生变化.结论 血清中的S-100B蛋白可作为病毒性脑炎患儿脑损伤的标志物,有助于病情的判定。
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