Abstract
ACTH and calcitonin concentrations in cerebrospinal fluid were measured in 22 patients with small cell carcinoma of the lung, including 14 patients with CNS metastases. ACTH concentrations were significantly higher in patients with CNS metastases as compared to those without. No difference was disclosed as regards calcitonin concentrations in cerebrospinal fluid between patients with and without CNS metastases. Measurement of ACTH in cerebrospinal fluid may be of diagnostic value in the detection of CNS metastases in patients with small cell carcinoma.
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