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Abstract
A new cerebroside, 1-O-beta-D-glucopyranosyl-(2S,3R,8E)-2-[(2'R)-2-hydroxy- palmitoylamino]-8-octadecene-1,3-diol, along with aralia cerebroside and 1-O-beta-D- glucopyranosyl-(2S,3S,4R,8E)-2-[(2'R)-2-hydroxybehenoylamino]-8-octadecene-1,3,4-triol were isolated from the roots of Serratula chinensis S. Moore. The structure of the new cerebroside was established by spectroscopic and chemical means. Occurrence of cerebrosides in Serratula is reported here for the first time.
Highlights
During the course of our continuing investigation of bioactive natural products found in folk medicinal plants from the southern part of mainland China, we have investigated the chemical constituents of S. chinensis roots and have reported in previous papers [3,4] the isolation of seven ecdysteroids and a mixture of five ceramides from that source
The EtOH extract of the powdered dry roots of S. chinensis was successively fractionated with petroleum ether, CHCl3 and n-BuOH
The CHCl3 fraction was separated by a combination of silica gel, Sephadex LH-20, and RP-18 silica gel column chromatography (CC) to yield compounds 1, 2, and 3 (Figure 1)
Summary
During the course of our continuing investigation of bioactive natural products found in folk medicinal plants from the southern part of mainland China, we have investigated the chemical constituents of S. chinensis roots and have reported in previous papers [3,4] the isolation of seven ecdysteroids and a mixture of five ceramides from that source. The EtOH extract of the powdered dry roots of S. chinensis was successively fractionated with petroleum ether, CHCl3 and n-BuOH. Methanolysis of 1 afforded a fatty acid methyl ester (FAME) and a long chain base (LCB) [6].
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