Abstract
The cerebroprotective effect of novel adamantane derivative of 2-pyrrolidone in rats with brain ischemia was studied. Pathology was modeled by irreversible occlusion of the common carotid arteries. In rats with experimental cerebral ischemia, there was a significant impairment of coordination of movements and sensory-motor functions: it was more difficult for animals to stay on the rotating rod, as well as in the «adhesive removal test» to notice and get rid of the sticker on the volar surface of the forepaws. In the «new object recognition» test, the animals of the control group showed impaired working memory. Course administration of the investigated derivative of 2-pyrrolidone and citicoline contributed to a significant correction of motor and cognitive impairments.
Highlights
The cerebroprotective effect of novel adamantane derivative of 2-pyrrolidone in rats with brain ischemia was studied
In rats with experimental cerebral ischemia, there was a significant impairment of coordination of movements and sensory-motor functions: it was more difficult for animals to stay on the rotating rod, as well as in the «adhesive removal test» to notice and get rid of the sticker on the volar surface of the forepaws
Course administration of the investigated derivative of 2-pyrrolidone and citicoline contributed to a significant correction of motor and cognitive impairments
Summary
CEREBROPROTECTIVE ACTIVITY OF NOVEL ADAMANTANE DERIVATIVE OF 2-PYRROLIDONE IN RATS WITH BRAIN ISCHEMIA The cerebroprotective effect of novel adamantane derivative of 2-pyrrolidone in rats with brain ischemia was studied. Исследуемое в данной работе новое каркасное производное альфа-пирролидона (соединение TIM-2) в предыдущих экспериментах показало наличие широкого спектра психотропной активности: анксиолитическое, антидепрессантное и ноотропное действие на интактных животных. При введении блокаторов хлорного канала ГАМК-А рецепторов (коразола и пикротоксина) соединение TIM-2 оказывало противосудорожное действие, что указывает на вероятный ГАМК-ергический механизм его активности и перспективность дальнейшего исследования церебропротекторного действия, свойственного средствам, влияющим на систему ГАМК [8].
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