Abstract
Background Cerebral venous thrombosis (CVT) is a disorder potentially leading to devastating disability and even death if not timely diagnosed and treated. While TOF MR venography is most commonly used for diagnosis, the accuracy can be compromised by the flow voids caused by a slow or complex flow pattern and in-plane flow saturation. Several other MR techniques, relying on characteristic image contrast of CVT, may also underor over-estimate the thrombus due to the signals from venous flow and other structures. High-spatial resolution dark-blood CMR could address the above issues, but, to our knowledge, has not been attempted. In this work, a fast dark-blood CMR technique was developed and validated in CVT patients.
Highlights
Cerebral venous thrombosis (CVT) is a disorder potentially leading to devastating disability and even death if not timely diagnosed and treated
To better detect CVT, in the subacute stage, we combined T1w SPACE with (a) a nonselective saturation pulse to exclude the T2-weighting that resides in the longitudinal magnetization at the end of the long echo train and (b) a DANTE preparation to suppress slow flow signals while introducing less T2-weighting
CNR analysis indicated that DANTE with 150 pulses appeared to be a suitable preparation to yield sufficiently clean sinus lumens while avoiding further signal loss in static tissues (Fig. 1A)
Summary
Cerebral venous thrombosis (CVT) is a disorder potentially leading to devastating disability and even death if not timely diagnosed and treated. While TOF MR venography is most commonly used for diagnosis, the accuracy can be compromised by the flow voids caused by a slow or complex flow pattern and in-plane flow saturation. Several other MR techniques, relying on characteristic image contrast of CVT, may under- or over-estimate the thrombus due to the signals from venous flow and other structures. High-spatial resolution dark-blood CMR could address the above issues, but, to our knowledge, has not been attempted. A fast dark-blood CMR technique was developed and validated in CVT patients
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