Abstract
I read with great interest the original article by Macedo-Campos et al 1 Macedo-Campos R.S. Adegoke S.A. Figueiredo M.S. et al. Cerebral vasoreactivity in children with sickle cell disease: a transcranial doppler study. J Stroke Cerebrovasc Dis 2018 pii: S1052-3057(18)30289-1. 2018; https://doi.org/10.1016/j.jstrokecerebrovasdis.2018.05.042 Abstract Full Text Full Text PDF Scopus (7) Google Scholar titled “Cerebral Vasoreactivity in Children with Sickle Cell Disease: A Transcranial Doppler Study.” Authors have explored the cerebrovascular reactivity assessed by breath-holding index (BHI) in the children with sickle cell disease (SCD). They have reported the impaired cerebrovascular reactivity in the children with SCD as compared to that of control subjects. However, few potential methodological limitations need to be addressed regarding this study. Cerebral Vasoreactivity in Children with Sickle Cell Disease: A Transcranial Doppler StudyJournal of Stroke and Cerebrovascular DiseasesVol. 27Issue 10PreviewImpairment of vasodilatory capacity reflecting reduced cerebrovascular reserve was previously shown in adults with sickle cell disease (SCD) and might play a role in the pathophysiology of stroke in such patients. We examined the hypothesis that children with SCD would also have a higher frequency of impaired cerebral vasoreactivity when compared with healthy age- and gender-matched controls. Full-Text PDF
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