Cerebral somatosensory potentials evoked by posterior tibial nerve stimulation: lateralization and relation to handedness in left-handed normal subjects.

Abstract

Somatosensory potentials evoked by stimulation of the right and left posterior tibial nerves were studied in left-handed normal subjects. Hand preference was assessed by the Edinburgh Handedness Inventory; a laterality score (Geschwind score) was calculated for each subject. Hand skill was assessed by the peg moving task. The mean amplitude of the N1 wave from the right cerebral cortex was found to be significantly larger than that from the left cerebral cortex. In the subjects without familial sinistrality, there was no statistically significant difference between the evoked potentials from the right and left sides. In the subjects with familial sinistrality, the mean amplitude of the N1 wave from the right cerebral cortex was found to be significantly larger than that from the left cerebral cortex. There was an inverse relationship between the lateralization quotient (LQ) for the N1 wave and left-hand preference. The amplitudes of the P1, N1, and P2 waves from the right cerebral cortex were positively linearly correlated with left-hand preference. There was an inverse relationship between LQ for the P1 and N1 waves and the right-hand skill. The left-hand skill was not correlated with LQ for the evoked potential. The LQs for the P1 and N1 waves were negatively linearly correlated with the difference between the right and left hand skills (right minus left peg moving times). The amplitudes of the P1 and N1 waves from the left cerebral cortex were found to be inversely related to the right hand skill. There was no relationship between the evoked potential amplitudes from the right cerebral cortex and left hand skill in the total sample. It was concluded that the stronger sensory feedback for the somatomotor foot area within the right cerebral cortex would contribute to left-footedness in left-handers; the asymmetric organization of the somatosensory potentials evoked by stimulation of the right and left PTNs correlates with hand preference and skill, but in an unexpected manner.