Abstract

Part I. Introduction. From First To Fourth Messengers in the Brain: An Overview, M. E.A. Reith. Part II. Memory. Cellular and Molecular Mechanisms of Learning and Memory, M. Lattal and T. Abel. Signal Transduction Pathways in Well-Defined Models of Learning and Memory: Drosophila and Honeybee, U. Muller. Protein Kinase C Signaling in Learning and Memory, E.A. Van der Zee, B.R.K. Douma, J.F. Disterhoft, and P.G.M. Luiten. Part III. Neurodegeneration and Apoptosis. Neurotransmitter Receptor G-Protein Mediated Signal Transduction in Alzheimer's Disease, R.F. Cowburn. The NO Signaling Pathway in the Brain: Neural Injury, Neurological Disorders, and Aggression, M. Sasaki, V. L. Dawson, and T. M. Dawson. Cellular Signaling Pathways in Neuronal Apoptosis: Role in Neurodegeneration and Alzheimer's Disease, C.W. Cotman, H. Qian, and A.J. Anderson. The Role of Second Messengers in Neurodegeneration, A. Frandsen, J. B. Jensen and A. Schousboe. Part IV. Depression. Molecular and Cellular Determinants of Stress and Antidepressant Treatment, R.S. Duman. Long-Term Bidirectional Hormonal and Neuroplastic Responses to Stress: Implications For the Treatment of Depression, R.M. Post, S.R.B. Weiss, L.-X. Zhang, and M.G. Xing. Signal Transduction Abnormalities in Bipolar Affective Disorder, P.P. Li, S. Andreopoulos, and J.J. Warsh. Part V. Drug Dependence. Messengers in Opioid Dependence: Gene Disruption Studies, R. Maldonado and O. Valverde. The 5-HT1B Knockout Mouse: An Animal Model of Vulnerability to Drugs of Abuse, K. Scearce-Levie and R. Hen. Regulation of Dopamine Transporter By Phosphorylation and Impact on Cocaine Action, R.A. Vaughan. Dopamine Transporter mRNA in Human Brain: Distribution and Regulatory Effects in Autopsy Studies of Cocaine Abusers, D.C. Mash, L.C. Kramer, D. Segal and S. Izenwasser. Index.

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