Abstract
Sepsis, the host’s reaction to infection, characteristically includes multi-organ dysfunction. Brain dysfunction is often one of the first clinical symptoms in sepsis and may manifest as sepsis-associated delirium in up to 70 % of patients [, ], less often as focal deficits or seizures []. As severely reduced global perfusion leading to hypotension, maldistribution of regional blood flow, and tissue hypoperfusion is a key feature of severe sepsis and septic shock, the question whether there is a link between cerebral perfusion and brain dysfunction in sepsis is obvious. However, clinical and experimental data on cerebral perfusion in sepsis are often inconsistent and most reports only include small numbers of animals or patients. We summarize the current literature on the effects of the inflammatory response on cerebral perfusion and review the effects of altered cerebral perfusion on brain function in sepsis.
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