Cerebral magnetic responses to noise bursts and pauses of different durations.

Abstract

We compared magnetic-evoked responses of human auditory cortex to short (5, 10, 20, 40, 80 and 160 ms) noise bursts and to pauses of identical durations in continuous noise. Onsets of both stimuli evoked responses with the most prominent deflection (N100m) peaking at about 100 ms. Both field maps could be explained by current dipoles, which agree with activity at the supratemporal cortex at slightly different locations. At the shortest 5-ms duration the noise bursts evoked a clear N100m whereas pauses elicited very low-amplitude responses or no response at all. For both stimuli, N100m increased in amplitude when the stimulus duration was increased from 5 up to 20-40 ms. The latencies were 10-20 ms longer for pauses than noise bursts with the longest latencies at the shortest stimulus durations. The differences in amplitudes and latencies as a function of stimulus duration and the slightly different source areas indicate that the generators of the on- and off-responses are not identical.