Abstract
BackgroundChronic myelomonocytic leukemia is a myelodysplastic/myeloproliferative neoplasm characterized by the infiltration of blood and bone marrow by immature monocytes. Cerebral localization of chronic myelomonocytic leukemia has never been described.Case presentationWe report the case of a Caucasian 59 year-old man with multiorgan chronic myelomonocytic leukemia infiltration, associated with uncommon brain involvement. There was no evidence of evolution to acute myeloid leukemia. The evidence of cerebral infiltration by chronic myelomonocytic leukemia was made after autopsy.ConclusionsThe fatal outcome of the patient raises the question of the potential benefit of early specific treatment, such as demethylating agents or intensive chemotherapy. Sharing such images of atypical and rapidly evolving chronic myelomonocytic leukemia and the disease history may help clinical decision-making in the future.
Highlights
ConclusionsThe fatal outcome of the patient raises the question of the potential benefit of early specific treat‐ ment, such as demethylating agents or intensive chemotherapy
Chronic myelomonocytic leukemia (CMML) is a malignant neoplasm that exhibits both myelodysplastic and myeloproliferative features and is characterized by peripheral monocytosis
The fatal outcome of the patient raises the question of the potential benefit of early specific treat‐ ment, such as demethylating agents or intensive chemotherapy
Summary
The fatal outcome of the patient raises the question of the potential benefit of early specific treat‐ ment, such as demethylating agents or intensive chemotherapy. Sharing such images of atypical and rapidly evolving chronic myelomonocytic leukemia and the disease history may help clinical decision-making in the future
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