Cerebral Ischaemia Secondary to Anticoagulant Treatment in a Haemophiliac Patient: A Case Report

Abstract

We report the case of a 21-year-old patient who had been treated for haemophilia A since the age of 8. He had a family history of haemophilia, as his maternal uncle also suffered from the disease. During his life, he had suffered several episodes of joint and muscle haemorrhages for which he had received replacement therapy with recombinant factor VIII (Kogenate). However, three months after his last treatment, the patient developed headaches and neurological deficits, in particular paresthesias in his lower limbs. Cerebral magnetic resonance imaging (MRI) revealed nodular and focal signal abnormalities in several brain regions, as well as minimal triventricular hydrocephalus with intraventricular haemorrhage. This clinical and radiological presentation led to the diagnosis of cerebral ischaemia secondary to anticoagulant treatment.