Abstract
Patients with lymphoma are predisposed to infection because of the immunocompromised state related to the disease itself and as a consequence of chemo-/radiotherapy. Here, we report a case of Herpes-simplex virus encephalitis (HSE) in an immunosuppressed patient with splenic marginal zone lymphoma (SMZL), a rare indolent variant of non-Hodgkin´s lymphoma (NHL). The course was complicated febrile neutropenia and HSV-1-related cerebral vasculitis causing progressive ischemic stroke. This case illustrates the expanding spectrum of atypical clinical and radiological manifestations of HSE in patients treated with myelotoxic drugs. Moreover, we summarize the few central nervous system manifestations of SMZL reported in the literature and discuss distinct causes of neurological deterioration in patients with NHL.
Highlights
Splenic marginal zone lymphoma (SMZL) is a rare indolent non-Hodgkin lymphoma (NHL)subtype that originates from B memory lymphocytes present in the marginal zone of secondary lymphoid follicles [1,2]
While the epidemiology of viral encephalitis is in constant turnover, Herpes-simplex virus (HSV)
A 60 year old male patient was diagnosed with splenic marginal zone lymphoma (SMZL), an indolent B-cell non-Hodgkins lymphoma (NHL), stage IVB
Summary
Raffaele Nardone 1,2 , Luca Carnicelli 1 , Francesco Brigo 1 , Slaven Pikija 2 , Larissa Hauer 3 and Johann Sellner 2,4,5, *.
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