Abstract
Twenty patients with PTE (16 men and 4 women, aged 35.5 ± 14.8years) underwent perfusion computed tomography (PCT), followed by anodal HD-tDCS and post-stimulation tomography at 21days after TBI. The Westermark perfusion maps were constructed and quantitative perfusion parameters calculated. Significance was preset to P<0.05. Qualitative analysis revealed that all patients had areas with reduced cerebral blood flow (CBF) and increased average mean transit time (MTT). HD-tDCS was accompanied by a significant decrease in the number of zones of both hypoperfusion and ischemia (p<0.05). Quantitative analysis showed that, in all patients, HD-tDCS caused a significant increase in CBF (p<0.001), cerebral blood volume (CBV) (p<0.01) and MTT shortening (p<0.05) in the frontotemporal region on the anode side. In the basal ganglia, a significant increase in CBF was found only in the five patients in whom this was initially reduced (p<0.01) and only with an anode placed on the same side. In patients with complications due to PTE TBI, HD-tDCS causes a significant increase in CBV, CBF and a decrease in the average MTT, suggesting better oxygen delivery to tissue.
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