Abstract
The diazepam withdrawal syndrome in rats was characterized behaviorally by an increase in spontaneous motor activity, slight body tremors and a lack of convulsions. The 2-deoxyglucose (2-DG) technique was used to measured quantitatively cerebral glucose utilization during diazepam withdrawal and revealed changes in glucose utilization in 30% of the 54 structures evaluated. Areas of increased glucose utilization included medial geniculate, inferior colliculus, visual cortex, mamillary body, dorsal hippocampus, cerebellar flocculus, and zona reticulata and zona compacta of the substantia nigra. Areas of decreased glucose utilization included columnar areas in frontal sensorimotor cortex, caudate, globus pallidus, olfactory cortex, nucleus accumbens and internal capsule. There was no single or consistent relationship between reported benzodiazepine receptor densities and glucose utilization.
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