Abstract
BackgroundTo estimate the association between post-term delivery and risk of physical disabilities, mental disabilities, and seizures during the first 7 years of life.MethodsData from 57,884 singleton infants born alive in week 39–45 by mothers included in the Danish National Birth Cohort (1997 to 2004) were analyzed, of these 51,268 were born at term (39–41 + 6) and 6616 post-term (42 + 0–44 + 6). Information on clinical endpoints was obtained from an interview at 18 months of gestational age, from a 7-year questionnaire, and from the Danish National Patient Register.Logistic regression and Cox regression were used to estimate odds ratios and hazard rate ratios for the outcome obtained from the interview/questionnaire data and from the register-based data, respectively.ResultsWe found no statistically significant increased risk of physical disabilities, mental disabilities, and epilepsy among children born post-term, though for most outcomes studied a tendency towards more adverse outcomes was seen. When children born late term (week 41) were compared to children born in week 42 or later the same tendency was found.ConclusionPost-term born children had a tendency to an excess risk of neurological disabilities as followed for up to 7 years of age.
Highlights
To estimate the association between post-term delivery and risk of physical disabilities, mental disabilities, and seizures during the first 7 years of life
Post-term delivery has been associated with increased perinatal mortality [1, 2] but newer studies do not support these findings, probably due to an improved management of post-term pregnancies [3, 4]
For unknown reasons post-term deliveries still seem to cause higher neonatal morbidity [2, 3], but it has been hypothesized to be caused by a decreased placental function in late pregnancy
Summary
The aim of this study was to examine if post-term born children were at higher risk of physical disabilities, mental disabilities, or seizures at the age of 7 years compared to children born at term
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